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2-Chloro-N6-cyclopentyladenosine, adenosine A1 receptor agonist, antagonizes the adenosine A3 receptor

✍ Scribed by Zhan-guo Gao; Kenneth A. Jacobson


Book ID
114014720
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
88 KB
Volume
443
Category
Article
ISSN
0014-2999

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## Abstract We studied effects of 2‐chloro‐N^6^‐(3‐iodobenzyl)‐adenosine‐5′‐N‐methyluronamide (Cl‐IB‐MECA) on apoptosis induction in the K562/Dox cell line, which overexpressed P‐glycoprotein (P‐gp, __ABCB1__, __MDR1__). We found that the K562/Dox cell line was significantly more resistant to Cl‐IB