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2-Chloro-2′-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4

✍ Scribed by Nomura, Y; Inanami, O; Takahashi, K; Matsuda, A; Kuwabara, M

Book ID: 110054433
Publisher: Nature Publishing Group
Year: 2000
Tongue: English
Weight: 164 KB
Volume: 14
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2401649

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## Abstract Exogenous β~2~‐microglobulin (β~2~m) induces significant apoptosis in the CCRF‐HSB‐2 human lymphoblastic leukemia cell line as detected by DNA fragmentation, DAPI staining and annexin V binding assay. β~2~m treatment induced the release of cytochrome c and apoptosis‐inducing factor (AIF