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2-Bromo-N-(2-Bromoethyl)-N-Carbethoxyethanamine, a Useful Reagent in the Synthesis of 4,4 Disubstituted Piperidines

✍ Scribed by Huybrechts, S.; Hoornaert, G. J.


Book ID
120562754
Publisher
Taylor and Francis Group
Year
1981
Tongue
English
Weight
198 KB
Volume
11
Category
Article
ISSN
0039-7911

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an Ο‰-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent