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2-aryl-indolyl maleimides - novel and potent inhibitors of protein kinase C

✍ Scribed by Robert T. Hendricks; Dan Sherman; Berta Strulovici; Chris A. Broka


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
369 KB
Volume
5
Category
Article
ISSN
0960-894X

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Phenylamino-pyrimidines represent a novel class of inhibitors of the protein kinase C with a high degree of selectivity versus other serindthreonine and tyrosine kinases. Steady state kinetic analysis of N-(3-[ 1 -imidazolyl]-phenyl)-4-(3-pyridyl)-2-pyrimidinamine (3, which showed potent inhibitory