Selective α1a adrenergic receptor antago
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Philippe G Nantermet; James C Barrow; Harold G Selnick; Carl F Homnick; Roger M
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Article
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2000
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Elsevier Science
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English
⚖ 144 KB
AbstractÐA series of a 1a receptor antagonists derived from a 4-aryl-3,4-dihydropyridine-2-one heterocycle is disclosed. Potency in the low nanomolar to picomolar range along with high selectivity was obtained. In vivo ecacy in a prostate contraction model in rats was observed with a few derivatives