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2-Amino-3-methylimidazo[4,5-f]quinoline-mediated immunosuppression involves inhibition of protein kinase C in murine splenocytes

✍ Scribed by Yong Woo Lee; Young Jin Jeon; Byung Sun Yoo; Kyu-Hwan Yang

Book ID: 116123585
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 916 KB
Volume: 107
Category: Article
ISSN: 0304-3835
DOI: 10.1016/0304-3835(96)04356-x

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## Abstract 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) and 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__)]pyridine (PhIP) are two members of a family of carcinogenic heterocyclic amines (HAs) found in cooked meats that form DNA adducts after activation to __N__‐acetoxy derivatives. The ability of IQ