2-Amino-1,3-thiazol-4(5 H )-ones as Potent and Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme−Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice

✍ Scribed by Johansson, Lars; Fotsch, Christopher; Bartberger, Michael D.; Castro, Victor M.; Chen, Michelle; Emery, Maurice; Gustafsson, Sonja; Hale, Clarence; Hickman, Dean; Homan, Evert; Jordan, Steven R.; Komorowski, Renee; Li, Aiwen; McRae, Kenneth; Moniz, George; Matsumoto, Guy; Orihuela, Carlos; Palm, Gunnar; Veniant, Murielle; Wang, Minghan; Williams, Meredith; Zhang, Jiandong

• Book ID: 120073737
• Publisher: American Chemical Society
• Year: 2008
• Tongue: English
• Weight: 276 KB
• Volume: 51
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm701551j