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2-Acetyl-1,8-dihydroxy-3,6-dimethylnaphthalene

✍ Scribed by Müller, G. ;Lutz, M. ;Lachmann, J.


Book ID
114511048
Publisher
International Union of Crystallography
Year
1994
Tongue
English
Weight
336 KB
Volume
50
Category
Article
ISSN
0108-2701

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The chiral intermediate diol (3S,4R)-trans-3,4-dihydro-3,4-dihydroxy-2,2dimethyl-2H-1-benzopyran-6-carbonitrile 2. was prepared for the total synthesis of a potassium channel opener drug candidate. The stereoselective acetylation of racemic lwas carded out with various lipases among which the lipase