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2-Acetoxyacrylonitrile: use as electrophile equivalent to acetaldehyde in the asymmetric Michael reaction using chiral imines

✍ Scribed by Laurent Keller; Cheikhou Camara; Antonio Pinheiro; Françoise Dumas; Jean d'Angelo

Book ID: 104211515
Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 81 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)01971-7

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✦ Synopsis

The asymmetric Michael addition reaction between a variety of chiral imines and 2-acetoxyacrylonitrile, an electrophile equivalent to acetaldehyde, was reported. The resulting adducts were obtained in fair yields and with de and ee ]95%.

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