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2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation

✍ Scribed by Zhu, Jin; Chen, Tong; Liu, Jie; Ma, Ruoqun; Lu, Weiqiang; Huang, Jin; Li, Honglin; Li, Jian; Jiang, Hualiang


Book ID
120056940
Publisher
Molecular Diversity Preservation International
Year
2009
Tongue
English
Weight
235 KB
Volume
14
Category
Article
ISSN
1420-3049

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✍ Aleem Gangjee; Hiteshkumar D. Jain; Sherry F. Queener πŸ“‚ Article πŸ“… 2005 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 75 KB

Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan