2-(1-Naphthylmethyl)-2-imidazoline hydrochloride (naphazoline hydrochloride), C14H15N2+.Cl−, an α-adrenergic agonist

The synthesis of the 14C and 2H-isotopom

The synthesis of the 14C and 2H-isotopomers of (R)-N-[2-(2′-ethoxyphenoxy)-ethyl]-N-2-[3-(4′-methoxy-3′-sulfonamido)-phenyl]-propylamine hydrochloride, an α1-adrenoreceptor antagonist

✍ William J. Wheeler; Klaus K. Schmiegel; David C. Hunden 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 552 KB

The synthesis of [14C]-and [2H]-labeled LY253351 (YM12617-I), a potent a,-receptor antagonist, which is potentially useful in the treatment of benign prostatic hypertrophy (BPH) is described. The [14C]-isotopomer was synthesized from [14C]-potassium cyanide in nine steps in 1.5% radiochemical yield.