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1α, 25-Dihydroxyvitamin D3 specific regulation of growth, morphology, and fibronectin in a human osteosarcoma cell line

✍ Scribed by Renny T. Franceschi; Wilbur M. James; Gerold Zerlauth

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
895 KB
Volume
123
Category
Article
ISSN
0021-9541

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✦ Synopsis

The ability of the hormonally active vitamin D metabolite, Ia,25-dihydroxyvitamin Dj, to affect cell growth, morphology and fibronectin production has been examined using the MG-63 human osteosarcoma cell line. Hormone treatment reduced cell growth rate, saturation density and ['Hlthymidine incorporation. Inhibition was specific for la,25-dihydroxyvitamin D3 relative to other vitamin D metabolites (la,25-dihydroxyvitamin D3 > 25-dihydroxyvitamin D3 > 24R,25-dihydroxyvitamin D3> D3), antagonized by high concentra-

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