## Abstract For Abstract see ChemInform Abstract in Full Text.
(1′R,3S)-2-Oxo-1-(1′-phenylethyl)piperidine-3-carboxylic acid: a case of a very strong intramolecular hydrogen bond
✍ Scribed by Lumbreras-García, Ana-María ;Galindo-Guzmán, Alberto ;Gnecco, Dino ;Terán, Joel-Luis ;Bernès, Sylvain
- Publisher
- International Union of Crystallography
- Year
- 2004
- Tongue
- English
- Weight
- 183 KB
- Volume
- 60
- Category
- Article
- ISSN
- 1600-5368
No coin nor oath required. For personal study only.
✦ Synopsis
The title compound, C 14 H 17 NO 3 , exhibits a very strong C OÁ Á ÁHÐO intramolecular hydrogen bond, characterized by an OÁ Á ÁH separation of 1.39 (7) A Ê and an OÐHÁ Á ÁO angle of 153 (5) .
📜 SIMILAR VOLUMES
The title compound, CGS 148248, was synthesized with a '%-label in the azepine ring in 14 steps starting with l-bromo-3-phenylpropane (1> and K1%N in an overall yield of 1.31%. The reaction of I with K 1 k N yielded the nitrile 2 which upon hydrolysis followed by ring closure gave a-tetral~ne-l-~~c
## Abstract 4‐Ethoxycarbonyl‐5‐phenyl‐2,3‐dihydrofuran‐2,3‐dione **1** reacts with aldehydes __via__ the acylketene intermediate **2** giving the 1,3‐dioxin‐4‐ones **3a‐e** and the 1,4‐bis(5‐ethoxycarbonyl‐4‐oxo‐6‐phenyl‐4__H__‐1,3‐dioxin‐2‐yl)benzene **4**, and a one step reaction between dibenzoy
The title compound, C 39 H 39 N 3 O 4 , although having potential C 2 molecular symmetry, crystallizes as an asymmetric conformer, due to a couple of strong intramolecular hydrogen bonds involving hydroxyl groups and a pyridine N atom. This geometrical feature explains why this compound behaves as a