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(1R, 2S)-(−)-mangochinine, a naturally-occurring dibenzopyrrocoline alkaloid from Manglietia chingii

✍ Scribed by Sheng-xiang Qiu; Chun Liu; Shou-xun Zhao; Zun-cheng Xia; Norman R. Farnsworth; Harry H.S. Fong


Book ID
104259340
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
250 KB
Volume
39
Category
Article
ISSN
0040-4039

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✍ Antonio Garcı́a Martı́nez; Enrique Teso Vilar; Amelia Garcı́a Fraile; Santiago d 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 192 KB

The preparation of enantiopure (1R,2S)-2-chloromethyl-3-oxocyclopentanecarboxylic acid 9, an interesting possible precursor of the antitumor agent sarkomycin, from a camphor-derived 3-hydroxymethylnorbornan-2-one is reported. The described procedure constitutes the first stereocontrolled approach to