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1.P.233 Molecular evidence of founder effect for four mutations in the low-density lipoprotein receptor gene in French Canadians with familial hypercholesterolemia

✍ Scribed by O. Couture; J. Morissette; D. Gaudet; M.-C. Vohl; C. Gagné; J. Bergeron; J.-P. Després; J. Simard

Book ID
119437281
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
188 KB
Volume
134
Category
Article
ISSN
0021-9150

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## Communicated by Lnp.chee Tsui Familial hypercholesterolemia (FH) has an estimated frequency of 1:154 among French Canadians in Northeastern Quebec, compared with 1:500 in most other populations. FH is caused by numerous mutations of the low-density lipoprotein (LDL) receptor gene, but only six