1P-0205 Functional analysis about the role of Smad3-dependent transforming growth factor-β signaling in neointimal hyperplasia

Role of Smad3, acting independently of t

Role of Smad3, acting independently of transforming growth factor-β, in the early induction of Wnt-β-catenin signaling by parathyroid hormone in mouse osteoblastic cells

✍ Yoshifumi Inoue; Lucie Canaff; Geoffrey N. Hendy; Itoko Hisa; Toshitsugu Sugimot 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 344 KB 👁 1 views

## Abstract Parathyroid hormone (PTH) exerts an anabolic action on bone but the mechanisms are incompletely understood. We showed previously that PTH interacts with the canonical Wnt‐β‐catenin signaling pathway via the transforming growth factor (TGF)‐β signaling molecule, Smad3, to modulate osteob