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1H,13C and 15N backbone assignments of cyclophilin when bound to cyclosporin A (CsA) and preliminary structural characterization of the CsA binding site

✍ Scribed by Placido Neri; Robert Meadows; Gerd Gemmecker; Edward Olejniczak; David Nettesheim; Timothy Logan; Robert Simmer; Rosalind Helfrich; Thomas Holzman; Jean Severin; Stephen Fesik


Book ID
115925603
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
695 KB
Volume
294
Category
Article
ISSN
0014-5793

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1H, 13C, and 15N assignments and seconda
✍ Robert X. Xu; David Nettesheim; Edward T. Olejniczak; Robert Meadows; Gerd Gemme πŸ“‚ Article πŸ“… 1993 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 998 KB

## Abstract The ^1^H, ^13^C, and ^15^N resonances of FKBP when bound to the immunosuppressant, ascomycin, were assigned using a computer‐aided analysis of heteronuclear double and triple resonance three‐dimensional nmr spectra of [U‐^15^N] FKBP/ascomycin and [U‐^15^N, ^13^C] FKBP/ascomycin. In addi