𝔖 Bobbio Scriptorium
✦   LIBER   ✦

1H NMR study on putative intramolecular hydrogen bonding for histamine H3-receptor agonists

✍ Scribed by Jari T. Kovalainen; Johannes A.M. Christiaans; Antti Poso; Jouko Vepsäläinen; Reino Laatikainen; Jukka Gynther

Book ID
104260918
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
216 KB
Volume
40
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Conformational stabilization by intramolecular hydrogen bonding of two histamine H 3receptor agonists is studied by ~H NMR. Stabilization of each individual conformation of the compounds by intramolecular hydrogen bonding is not strong at physiological pH and temperature. However, 52% -61% of the molecules exist in conformations where an intramolecular hydrogen bond is possible.

📜 SIMILAR VOLUMES

1H NMR studies of solvent and substituen
1H NMR studies of solvent and substituent effects on strong intramolecular hydrogen bonds
✍ Bogumił Brzezinski; Miroslaw Szafran 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 476 KB

## Abstract Chemical shifts of H‐bonded protons in tetrabutylammonium hydrogen maleate and 14‐substituted picolinic acid __N__‐oxides have been measured in a number of dry solvents, of different activity, in order to distinguish between symmetrical single minimum and asymmetrical hydrogen bonds. In

1H NMR studies on intramolecular hydroge
1H NMR studies on intramolecular hydrogen bonding in perchlorates of N-(pyridyl)amides of 6-methylpicolinic acid N-oxide
✍ Bogumil Brzezinski 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 347 KB

## Abstract The ^1^H NMR spectra of perchlorates of __N__‐(pyridyl)amides of 6‐methylpicolinic acid __N__‐oxide (PYAP) in CD~3~CN at 100 MHz show two proton signals belonging to two distinct intramolecular hydrogen bonds. The position of these signals is independent of concentration and temperature

NMR of Enaminones Part 3—1H, 13C and 17O
NMR of Enaminones Part 3—1H, 13C and 17O NMR Spectroscopic Studies of Acyclic and Cyclic N-Aryl Enaminones: Substituent Effects and Intramolecular Hydrogen Bonding
✍ Jin-Cong Zhuo 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 303 KB 👁 2 views

17O, 13C and 1H NMR spectra for paraand meta-substituted 4-arylaminopent-3-en-2-ones (acyclic enaminones, 1 and 2) and 3-arylaminocyclohex-2-en-1-ones (cyclic enaminones, 3 and 4) are reported. The 17O, 13C and 1H shift values of these enaminones correlate well with and constants in the correlations

Density functional theory studies of tra
Density functional theory studies of transannular 1H1H J-coupling in half-cage alcohols and rigid 1,3- and 1,4-diols: conformational dependencies and implications for intramolecular hydrogen bond detection in carbohydrates
✍ Michael Barfield; Jon M. Bergset; Daniel J. O'Leary 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 426 KB

Density functional theory (DFT) methods were used to investigate the conformational dependence of transannular H-H coupling constants in half-cage alcohols and cage diols. Finite perturbation theory (FPT) was used to obtain the Fermi contact (FC) contributions to scalar coupling constants in three h