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1H NMR study of low-affinity binding of ibuprofen to human serum albumin at different pH

โœ Scribed by C. -G. Li; M. -L. Liu; C. -H. Ye


Publisher
Springer Vienna
Year
2000
Tongue
English
Weight
489 KB
Volume
19
Category
Article
ISSN
0937-9347

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The binding of racemic, (R)([) and (S)(])-ibuprofen (IBP) to human serum albumin (HSA) was studied using NMR spectroscopy. Having saturated the tight binding sites, the extent of weak binding was then investigated. The molecular di โ€ usion coefficients of IBP in HSA solution at di โ€ erent concentratio