N-(3,4-dimethoxyphenethyl)-4-(6,7-dimeth
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Amit S. Kalgutkar; Kosea S. Frederick; Jonathan Chupka; Bo Feng; Sarah Kempshall
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Article
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2009
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John Wiley and Sons
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English
⚖ 193 KB
The utility of the diaminoquinazoline derivative CP-100,356 as an in vivo probe to selectively assess MDR1/BCRP-mediated drug efflux was examined in the rat. CP-100,356 was devoid of inhibition (IC 50 >50 mM) against major human P450 enzymes including P4503A4. In human MDR1-transfected MDCKII cells,