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1H NMR and IR spectra of antitumour anthracyclines: Effect of the substitution pattern on the chemical shift values of the phenolic protons and on IR absorptions of the quinone system

✍ Scribed by Aristide Vigevani; Marzia Ballabio; Elena Gandini; Sergio Penco

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 682 KB
Volume: 23
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260230513

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✦ Synopsis

HNMR and IR data of numerous natural and synthetic analogues of daunorubicin and doxorubicin, anthracycline antibiotics successtully used in the clinical treatment of human tumours, have been recorded. The chemical shift values of the phenolic protons of approximately 130 compounds are reviewed and discussed with the aim of establishing a relationship between 6 values and structural features. The IR absorptions of the quinone system in the region 1560-1680 an-' are also examined.

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