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1H MRS studies in the Finnish boron neutron capture therapy project: Detection of 10B-carrier, l-p-boronophenylalanine-fructose

✍ Scribed by M. Timonen; L. Kankaanranta; N. Lundbom; J. Collan; A. Kangasmäki; M. Kortesniemi; A.-M. Häkkinen; A. Lönngren; S. Karjalainen; M. Rasilainen; J. Leinonen; T. Huitti; J. Jääskeläinen; M. Kouri; S. Savolainen; S. Heikkinen


Book ID
116439072
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
202 KB
Volume
56
Category
Article
ISSN
0720-048X

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The complex of L-p-boronophenylalanine (L-p-BPA) with fructose has been used for the past 5 years in clinical trials of boron neutron capture therapy to treat both melanoma and glioblastoma multiforme. However, the structure of this complex in water buffered at physiologic pH has not been establishe