1H chemical shift imaging of the human brain at age 60–90 years reveals metabolic differences between women and men
✍ Scribed by P.E. Sijens; M. Oudkerk; F.E. de Leeuw; J.C. de Groot; E. Achten; R. Heijboer; A. Hofman; M.M.B. Breteler
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 242 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
H magnetic resonance spectroscopy was used to compare brain metabolism in 540 elderly persons, stratified by sex and age (60-90 years old). An 8 ؋ 8 ؋ 2 cm 3 supraventricular brain volume, a transverse plane parallel to the canthomeatal line, was examined by automated 1 H chemical shift imaging [pointresolved spectroscopy (PRESS), TE of 35 msec]. Regional choline (Cho), creatine (Cr), and N-acetyl aspartate (NAA) peak areas in the 518 successful examinations (96%) were studied by division through the total area of the particular metabolite in each spectral map. This procedure eliminated intersubject variance, maximized intervoxel variance (26 I F I 149, P F 0.0001) and reduced the standard deviations in the voxel metabolite signals threefold. Normalized signals in women (n ؍ 257) and men (n ؍ 261) differed in 9 (Cho/⌺Cho), 8 (Cr/⌺Cr), and 10 (NAA/⌺NAA) of 36 voxels examined (P I 0.001). In the cingulate gyrus Cho/⌺Cho, Cr/⌺Cr, and NAA/⌺NAA were reduced in men compared with women. These findings are consistent with a sex-related reduction of glucose metabolism in the same brain lobe revealed by positron emission tomography. Magn