1H and 31P NMR measurement of cerebral lactate, high-energy phosphate levels, and pH in humans during voluntary hyperventilation: associated EEG, capnographic, and doppler findings
✍ Scribed by P. C. van Rijen; P. R. Luyten; J. W. Berkelbach Van der Sprenkel; V. Kraaier; A. C. van Huffelen; C. A. F. Tulleken; J. A. den Hollander
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 684 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
In order to explore the sensitivity of spatially resolved 'H and "P NMR spectroscopy on a whole-body NMR instrument, cerebral metabolic changes in human volunteers were measured during hyperventilation provocation. During hyperventilation the flow velocity in the middle cerebral artery decreased significantly and the EEG showed a marked increase in slow activity. 'H NMR spectra revealed an increase in cerebral lactate concentration. 3'P NMR spectra showed no changes in ATP or PCr peak heights, but a shift toward tissue alkalosis was derived from changes in Pi chemical shift. During subsequent recovery, lactate concentration decreased and a slight intracellular acidosis was detected. In three experiments broadening of the lactate resonance peak resulted in separation into two components at 1.32 and 1.48 ppm, in which the latter signal possibly arose from alanine. o 1989 Academic press. Inc.
Copyri&l Q 1989 by Academic Re%, Ioc.
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