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1H and 13C NMR study of the antihypertensive drugs nifedipine, nicardipine and related compounds

✍ Scribed by Martha S. Morales-Ríos; Alejandra De la Cerda Medina; Victor Pérez-Alvarez; Pedro Joseph-Nathan

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
54 KB
Volume
38
Category
Article
ISSN
0749-1581

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✦ Synopsis

One-bond and long-range two-dimensional 1 H and 13 C NMR experiments and deuterium-induced 13 C isotope shifts n C(ND) allow the unequivocal assignment of 13 C and 1 H spectra. On this basis, previous assignments of biologically active nifedipine, nicardipine and related compounds have been revised. The nicardipine chloride salt shows at room temperature two diastereoisomeric configurations due to the asymmetry of substitution at the restricted inverting nitrogen on the NMR time-scale.

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