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1H and 13C NMR study of 2-hydroxyglutaric acid and its lactone

✍ Scribed by Dominika Bal; Adam Gryff-Keller

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 97 KB
Volume: 40
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1053

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✦ Synopsis

Abstract

Determination of the level and absolute configuration of 2‐hydroxyglutaric acid in a patient's urine is a method of diagnosing two metabolic diseases. Such a determination can be done with the aid of NMR spectroscopic methods. In this paper the careful interpretation of ^1^H and ^13^C NMR spectra of this metabolite and its lactone measured under conditions used in biomedical assays is reported. The ^1^H chemical shifts and spin–spin coupling constants were derived using the total lineshape analysis method. Copyright © 2002 John Wiley & Sons, Ltd.

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