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1H and 13C-NMR and biological activity investigations of four lichen-derived compounds

✍ Scribed by Gabriele M. König; Anthony D. Wright

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
93 KB
Volume
10
Category
Article
ISSN
0958-0344

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✦ Synopsis

The lichen-derived natural products, atranorin (1), hopane-6a, 22-diol (2), usnic acid (3), and vulpinic acid (4) were analysed by both one and two-dimensional ( 1 H, 13 C)-NMR. Experiments employed included COSY, NOESY, XHCO, HMQC and HMBC. For 1 and 2, fully assigned proton NMR data are reported for the first time; the reassigned 13 C NMR data for both 1 and 2 are also reported. For 3, cross-peaks were observed in the HMBC spectrum that suggest that CH long-range coupling through H bonds is occurring. Biological activity investigations of each compound indicated hopane-6a, 22-diol (2) to have anti-tubercular activity (MIC 8 mg/mL) and usnic acid (3) to be very weakly cytotoxic (ED 50 13 mg/mL).

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