1H and 13C assignments of two new macrocyclic lactones isolated from Streptomyces sp. 211726 and revised assignments of Azalomycins F3a, F4aand F5a
✍ Scribed by Ganjun Yuan; Haipeng Lin; Cheng Wang; Kui Hong; Yue Liu; Jia Li
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 151 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0749-1581
- DOI
- 10.1002/mrc.2697
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✦ Synopsis
Abstract
Azalomycin F~4a~ 2‐ethylpentyl ester (1) and Azalomycin F~5a~ 2‐ethylpentyl ester (2), two new macrocyclic lactones, along with three known compounds of Azalomycins F~3a~ (3), F~4a~ (4) and F~5a~ (5), were identified from metabolites of Streptomyces sp. 211726 isolated from mangrove rhizosphere soil. The complete ^1^H and ^13^C assignments of these compounds were achieved by using ^1^H, ^13^C, DEPT, HSQC, ^1^H‐^1^H COSY and HMBC spectra, and the relative stereochemistry of 5 was first elucidated on the basis of proton–proton coupling constants, NOESY and IR spectra. Moreover, some errors in the ^1^H and ^13^C assignments published of 3, 4 and 5 were found and revised. 1 and 2 were active against Candida albicans, and exhibited moderate cyctotoxicity against HCT‐116 cell line. Copyright © 2010 John Wiley & Sons, Ltd.