19p + marker chromosome correlates with relapse in malignant fibrous histiocytoma
✍ Scribed by Peter F. M. Choong; Nils Mandahl; Fredrik Mertens; Helena Willén; Thor Alvegård; Andris Kreicbergs; Felix Mitelman; Anders Rydholm
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 377 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
In this study, we examined the relationship of I9p I 3 aberrations, usually leading to addition of unknown material ( I9p + ), and ring chromosomes to clinical outcome in patients with malignant fibrous histiocytoma (MFH). Analysis of 69 MFHs revealed 19 tumors with 19p+ and 24 tumors with ring chromosomes. After a median follow-up period of 36 months, 24 patients developed metastases, and 27 patients developed local recurrences. Ten patients had both local recurrences and metastases.
Local recurrence was more common in association with I9p + than without. Metastasis was more common with I9p + tumors in high-risk patients (tumor size >5 cm and grade IIUV; n = 48) than those without I9p + . There was a trend suggesting fewer relapses after tumors with ring chromosomes. I9p + may be an independent marker of unfavorable outcome in MFH. Genes Chromosom Cancer 16: 88-93 (1996). 0 I996 Wiley-Liss, Inc.