19F NMR studies of enflurane elimination and metabolism

✍ Scribed by N. E. Preece; J. Challands; S. C. R. Williams

• Book ID: 102960148
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 595 KB
• Volume: 5
• Category: Article
• ISSN: 0952-3480
• DOI: 10.1002/nbm.1940050209

✦ Synopsis

Abstract

The elimination and metabolism of enflurane, a fluorinated ether anaesthetic, was studied by ^19^F NMR in vivo in both rat liver and brain as well as human body fluids. In the liver of thiobarbitone‐anaesthetized rats the half‐life for enflurane following exposure to 0.15% (v/v) for 30 min was 76 min but this could be decreased to 39 min by pretreatment of the animals with isoniazid (0.1% in the drinking water for 7 days), an agent known to enhance enflurane metabolism. In these animals the major organic metabolite difluoromethoxy difluoroacetate (DFMDFA) was also detected by ^19^F NMR in vivo. This metabolite was detected along with fluoride ion in rat and human urine and plasma by high resolution ^19^F NMR. Human urine also contained signals from a probable DFMDFA conjugate and unexpectedly from trifluoroacetate.