19F-MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation

✍ Scribed by Simone Laukemper-Ostendorf; Alexander Scholz; Katja Bürger; Claus P. Heussel; Marc Schmittner; Norbert Weiler; Klaus Markstaller; Balthasar Eberle; Hans-Ulrich Kauczor; Michael Quintel; Manfred Thelen; Wolfgang G. Schreiber

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 328 KB
• Volume: 47
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.10008

✦ Synopsis

Abstract

A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed. A pulse sequence for high‐resolution MRI of the distribution of PFOB in the lung after intratracheal administration was developed as well. Moreover, quantitative measurements of longitudinal relaxation time T~1~ of ^19^F resonances for assessment of regional pO2 are described. Due to the need to acquire data during a single expiratory breathhold, only low SNRs were achieved in vivo. Therefore, simulations were performed to investigate the influence of background noise on T~1~ values calculated from data with low SNR. Based on these simulations, a postprocessing strategy was developed to correct for systematic errors by background noise prior to quantitative analysis. Results of a pilot study in pigs under conditions of PLV are presented. Magn Reson Med 47:82–89, 2002. © 2002 Wiley‐Liss, Inc.