19F Gel-Phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading
โ Scribed by Joseph M. Salvino
- Book ID
- 101972601
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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๐ SIMILAR VOLUMES
Solid-phase synthesis is an attractive approach for the generation of large numbers of compounds for biological studies, for instance in the pharmaceutical industry. [1] In addition, automated procedures for solid-phase synthesis of oligopeptides and oligonucleotides have been of major importance in
## Abstract This paper describes the manual Fmoc/__t__โBu solidโphase synthesis of a difficult nineโresidue hydrophobic peptide LLLLTVLTV from one of the signal sequences that flank the tandem repeat of the mucin MUC1. Gelโphase ^19^F NMR spectroscopy was used as a straightforward method for optimi
## Abstract __N__โ[1โ(4โ(4โfluorophenyl)โ2,6โdioxocyclohexylidene)ethyl] (Fde) protected amino acids have been prepared and applied in solidโphase peptide synthesis monitored by gelโphase ^19^F NMR spectroscopy. The Fde protective group could be cleaved with 2% hydrazine or 5% hydroxylamine solutio