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197 P73 JOINS P53 AS A REGULATOR OF MICRORNAS IN HEPATOCELLULAR CARCINOMA

✍ Scribed by M.H. Bender; L.C. Koenig; N. Joschko; B. Besenbeck; R. Pschowski; W. Stremmel; M. Müller

Book ID
117379343
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
55 KB
Volume
54
Category
Article
ISSN
0168-8278

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Loss of heterozygosity (LOH) at 1p36 occurs in a number of solid tumors including hepatocellular carcinoma (HCC). Recently, a novel gene, p73, has been identified at 1p36.33. p73 is structurally and functionally related to p53 located at 17p13.1, which is a target for inactivation in HCCs. p73 produ