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[18F]Fluoromethyl Iodide ([18F]FCH2I): Preparation and Reactions with Phenol, Thiophenol, Amide and Amine Functional Groups.

✍ Scribed by Ming-Rong Zhang; Masanao Ogawa; Kenji Furutsuka; Yuichiro Yoshida; Kazutoshi Suzuki

Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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How to increase the reactivity of [18F]fluoroethyl bromide: [18F]fluoroethylation of amine, phenol and amide functional groups with [18F]FEtBr, [18F]FEtBr/NaI and [18F]FEtOTf
✍ Ming-Rong Zhang; Kenji Furutsuka; Yuichiro Yoshida; Kazutoshi Suzuki πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 French βš– 124 KB

## Abstract [^18^F]Fluoroethyl bromide ([^18^F]FEtBr) is a useful synthetic precursor to synthesize ^18^F‐labeled compounds. However, the lower reactivity of [^18^F]FEtBr with amine, phenol and amide functional groups than that of [^11^C]CH~3~I partly limits its wide application in the synthesis of