[18F]fluoride production with a circulating [18O]water target

✍ Scribed by Ren Iwata; Tatsuo Ido; Frank Brady; Toshihiro Takahashi; Akira Ujiie

• Publisher: Elsevier Science
• Year: 1987
• Weight: 674 KB
• Volume: 38
• Category: Article
• ISSN: 0883-2889
• DOI: 10.1016/0883-2889(87)90272-3

✦ Synopsis

8F]fluoride was produced via the '*O(p,n)'*F reaction with a circulating 20% enriched ['*O]water target. Parameters affecting the production yield of ["Flfluoride such as beam current, beam profile, irradiation time, target thickness, circulation rate, and window material were investigated and optimized. With a 20 PA irradiation of 2.5 mL ['*O]water circulated at a flow rate of over 35 mL/min, a ["Flfluoride yield of more than 70% was obtained when the beam was defocussed and wobbled to get a uniform beam profile. In addition, radiolytically produced gases were recombined using a Pd catalyst into the target.