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[18F]-Dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

โœ Scribed by Pramod K. Pal; Joanne Leung; Katya Hedrich; Ali Samii; Abraham Lieberman; Paul A. Nausieda; Donald B. Calne; Xandra O. Breakefield; Christine Klein; A. Jon Stoessl

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
171 KB
Volume
17
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of (18)F-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the parkin gene.

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