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189. Surrogate markers in the treatment of dysthymia

✍ Scribed by E. Dunn; M. Coote; B. Helpard; M. Jones; J. Roberts; G. Browne; B. Bell; M. Steiner


Book ID
118512901
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
144 KB
Volume
43
Category
Article
ISSN
0006-3223

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In this paper, we measure the extent to which a biological marker is a surrogate endpoint for a clinical event by the proportional reduction in the regression coefficient for the treatment indicator due to the inclusion of the marker in the Cox regression model. We estimate this proportion by applyi