Pyrazolobenzodiazepines: Part I. Synthes
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Jin-Jun Liu; Irena Daniewski; Qingjie Ding; Brian Higgins; Grace Ju; Kenneth Kol
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Article
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2010
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Elsevier Science
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English
⚖ 472 KB
A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure-activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK2 activity in vitro, and block cell cycle