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18 Differential priming of T cells by antigens expressed in hepatocytes and cholangiocytes in animal models of autoimmune hepatitis and cholangitis

โœ Scribed by K. Derkow; S. Vierich; N. Kruse; K. Klugewitz; J. Mintern; B. Wiedenmann; T. Berg; H. Ploegh; E. Schott

Book ID
117374300
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
134 KB
Volume
44
Category
Article
ISSN
0168-8278

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โœ Katja Derkow; Christoph Loddenkemper; Justine Mintern; Nils Kruse; Katja Klugewi ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 946 KB

The pathogenesis of autoimmune liver diseases is poorly understood. Animal models are necessary to investigate antigen presentation and priming of T-cells in the context of autoimmunity in the liver. Transgenic mouse models were generated in which the model antigen ovalbumin is expressed in hepatocy