17β-estradiol in vitro affects Na-dependent and depolarization-induced Ca2+transport in rat brain synaptosomes

Ca2+-dependent protein kinase C isoforms

Ca2+-dependent protein kinase C isoforms are critical to estradiol 17β-D-glucuronide–induced cholestasis in the rat

✍ Fernando A. Crocenzi; Enrique J. Sánchez Pozzi; María Laura Ruiz; Andrés E. Zucc 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 702 KB

The endogenous estradiol metabolite estradiol 17beta-D-glucuronide (E(2)17G) induces an acute cholestasis in rat liver coincident with retrieval of the canalicular transporters bile salt export pump (Bsep, Abcc11) and multidrug resistance-associated protein 2 (Mrp2, Abcc2) and their associated loss