17β-estradiol attenuates α, β-meATP-induced currents in rat dorsal root ganglion neurons
✍ Scribed by Bei Ma; Weifang Rong; Philip M. Dunn; Geoffery Burnstock
- Book ID
- 116717796
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 244 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0024-3205
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A mechanism underlying gender-related differences in pain perception may be estrogen modulation of nociceptive signaling in the peripheral nervous system. In rat, dorsal root ganglion (DRG) neurons express estrogen receptors (ERs) and estrogen rapidly attenuates ATP-induced Ca2+ signaling. To determ
Estradiol attenuates the ATP-induced increase of intracellular calcium concentration ([Ca(2+)](i)) in rat dorsal root ganglion (DRG) neurons by blocking the L-type voltage gated calcium channel (VGCC). Because ATP is a putative nociceptive signal, this action may indicate a site of estradiol regulat