17O-NMR, EPR and NMRD Characterization of [Gd(DTPA-BMEA)(H2O)]: A Neutral MRI Contrast Agent
✍ Scribed by Éva Tóth; Fabienne Connac; Lothar Helm; Kofi Adzamli; André E. Merbach
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 171 KB
- Volume
- 1998
- Category
- Article
- ISSN
- 1434-1948
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✦ Synopsis
A study including variable-temperature and -pressure,
The longer rotational correlation time of [Gd(DTPA-BMEA)(H 2 O)], as obtained from a global multiple-field 17 O NMR, EPR and NMRD has been performed on the MRI contrast agent, [Gd(DTPA-analysis of 17 O-NMR, EPR and NMRD data, and compared to that of [Gd(DTPA-BMA)(H 2 O)], can be explained by water BMEA)(H 2 O)]. The water exchange rate [k ex 298
= (0.39 ± 0.02) × 10 6 s -1 ] and the activation volume (∆V ϶ = +7.4 ± 0.4 cm 3 molecules hydrogen-bonded to the ether oxygen atoms of the ligand side chain. mol -1 ), hence the mechanism, are identical to those for