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179 Oxidative stress reduces nitric oxide biodisponibility and may contribute to endothelial dysfunction of cirrhotic livers

✍ Scribed by J. Gracia-Sancho; B. Laviña; A. Rodríguez-Vilarrupla; H. García; J. Bosch; J.C. García-Pagán


Book ID
117374459
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
118 KB
Volume
44
Category
Article
ISSN
0168-8278

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Increased oxidative stress in cirrhotic
✍ Jorge Gracia-Sancho; Bàrbara Laviña; Aina Rodríguez-Vilarrupla; Héctor García-Ca 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 612 KB

In cirrhotic livers, decreased nitric oxide (NO) bioavailability is a major factor increasing intrahepatic vascular tone. In several vascular disorders, an increase in superoxide (O 2 ؊ ) has been shown to contribute to reduced NO bioavailability through its reaction with NO to form peroxynitrite. T