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172 P - Inhibition of BCL-2 by antisense oligonucleotides reduces tumor size and reduces chemotesistance of human melanoma in SCID mice

✍ Scribed by B. Jansen; H. Wadl; S.A. Inoue; B. Brown; B. Bryan; H.-G. Eichler; K. Wolff; H. Peharmbrger


Book ID
116168449
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
173 KB
Volume
32
Category
Article
ISSN
0959-8049

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We have reported that antisense Bcl-2 oligodeoxynucleotide (ODN) delays progression to androgen independence in the androgen-dependent (AD) mouse Shionogi tumor model. Here, we characterize changes in bcl-xL, another important anti-apoptotic gene, and test the efficacy of adjuvant antisense Bcl-xL O