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17 β-Estradiol may affect vulnerability of striatum in a 3-nitropropionic acid-induced experimental model of Huntington's disease in ovariectomized rats

✍ Scribed by Isaac Túnez; Juan A. Collado; Francisco J. Medina; José Peña; María del C. Muñoz; Ignacio Jimena; Francisco Franco; Ignacio Rueda; Montserrat Feijóo; Jordi Muntané; Pedro Montilla

Book ID: 116764758
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 290 KB
Volume: 48
Category: Article
ISSN: 0197-0186
DOI: 10.1016/j.neuint.2005.11.011

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## Abstract Symptoms in the early stages of Huntington's disease (HD) are assumed to reflect basal ganglia circuit dysfunction secondary to degeneration of striatal projections to the external segment of the globus pallidus (GPe). The hypothesis that GPe lesion would ameliorate HD symptoms by “norm