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17-β-Estradiol activates maxi-K channels through a non-genomic pathway in human breast cancer cells

✍ Scribed by Guyllaume Coiret; Fabrice Matifat; Frédéric Hague; Halima Ouadid-Ahidouch


Book ID
116465459
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
295 KB
Volume
579
Category
Article
ISSN
0014-5793

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## Abstract Cdc25A is a potent tyrosine phosphatase that catalyzes specific dephosphorylation of cyclin/cyclin‐dependent kinase (cdk) complexes to regulate G~1~ to S‐phase cell cycle progression. Cdc25A mRNA levels are induced by 17β‐estradiol (E2) in ZR‐75 breast cancer cells, and deletion analysi