17β-estradiol (E2) induces cdc25A gene e
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Wan Ru Lee; Chien-Cheng Chen; Shengxi Liu; Stephen Safe
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Article
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2006
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John Wiley and Sons
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English
⚖ 259 KB
## Abstract Cdc25A is a potent tyrosine phosphatase that catalyzes specific dephosphorylation of cyclin/cyclin‐dependent kinase (cdk) complexes to regulate G~1~ to S‐phase cell cycle progression. Cdc25A mRNA levels are induced by 17β‐estradiol (E2) in ZR‐75 breast cancer cells, and deletion analysi