168 Grp78 activity is associated with Androgen Receptor status and upregulated in Hormone-Refractory prostate cancer
β Scribed by S. Tan; I. Ahmad; L. Singh; C. Nixon; J. Edwards; H. Leung
- Book ID
- 119601956
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 47 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1359-6349
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p53 protein expression of 30 hormone-refractory locally recurrent prostate cancers was compared with their matched untreated primary tumour specimens. In addition, androgen receptor (AR) gene amplification and p53 protein immunostaining were compared. p53 positivity increased during hormonal therapy
## Abstract The androgen receptor (AR), a steroid receptor family member, is a ligandβdependent transcription factor that has an integral role in normal prostate development. Alterations in ARβmediated activity can result in abnormal gene expression, dysregulated cell growth and prostate cancer. Co