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167. The proliferative rates of acute myelogenous leukemia cells can be accelerated or slowed in vivo in patients

โœ Scribed by Preisler, HD; Raza, A; Larson, R


Book ID
122496492
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
138 KB
Volume
46
Category
Article
ISSN
0753-3322

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## Abstract Typical multiโ€drug resistance (MDR) in human and animal cell lines is caused by overactivity of a unidirectional drug efflux pump. This pump is composed of a 170โ€kDa transmembrane glycoprotein (Pโ€glycoprotein) that is encoded by the soโ€called __mdrl__ gene. The functionally relevant cha