16,19-cis-murisolin and murisolin a, two novel bioactive mono-tetrahydrofuran annonaceous acetogenins from Asimina triloba seeds

✍ Scribed by Mi Hee Woo; Lu Zeng; Qing Ye; Zhe-Ming Gu; Geng-Xian Zhao; Jerry L. McLaughlin

• Book ID: 103982944
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 347 KB
• Volume: 5
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(95)00182-s

✦ Synopsis

Two novel bioactive mono-tetrahydrofuran (THF) 7-1actone acetogenins, 16,19-cis-murisolin (1) and murisolin A (2), were isolated from the seeds of Asimina triloba (Annonaceae) by directing the fractionation with brine shrimp lethality. 1 has a 16,19-cis mono-THF ring with two flanking hydroxyl groups and represents a new type among the natural Annonaceous acetogenins. Murisolin (3), which is new in this species, was also obtained. 1-3 showed potent and selective cytotoxicities among six human tumor cell lines.

Asimina triloba (L.) Dunal (paw paw) is one of several species of the genus Asimina (Annonaceae) which