16,16-Dimethyl-PGE2 Protection Against α — Napthy lisothiocy anate – Induced Experimental Cholangitis in the Rat
✍ Scribed by Mary J. Ruwart; Bob D. Rush; Nanette M. Friedle; Jerzy Stachura; Andrzej Tarnawski
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 340 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
Male rats were treated with subcutaneous vehicle or 16,16-dimethyl-PGEz (dmPGEn, 100 pg per kg), 24,18 and 0.6 hr prior to and 6 , 2 4 and 30 hr after challenge with oral a-napthylisothiocyanate (ANIT, 30 mg per kg). Forty-eight hours after challenge, rats were sacrificed by decapitation; serum and liver samples were taken for biochemical and histological analysis, respectively. Rats treated with vehicle (2% ethanol in saline) and ANIT exhibited elevations in alkaline phosphatase, SGPT and bilirubin as well as cholangitis and mild parenchymal necrosis. Rats treated with dmPGEz and ANIT had normal serum biochemical findings, no necrosis and only mild proliferation of bile duct epithelium. Thus, dmPGEz may be able to protect the rat liver against the deleterious effects of orally administered ANIT.